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Models for aaRS-related CMT in D. melanogaster.
| Human Gene |
D. melanogaster Orthologue % Identity at Protein Level |
Modeled CMT Mutation | Reference |
|---|---|---|---|
| hGARS1 |
GlyRS (dGARS) 54 |
E71G | [44,65] |
| L219P | [65] | ||
| P234KY * | [43,64] | ||
| G240R | [43,44,64] | ||
| G526R | [44] | ||
| hYARS1 |
TyrRS (dYARS) 67 |
G41R | [33,43,44] |
| E196K | |||
| 153–156delVKQV | |||
| K265N | [66] |
*—corresponding to P278KY in the mouse orthologue; dGARS & dYARS: D. melanogaster orthologues, hYARS1 & hGARS1: human orthologues.
