Table 1. Demographic, parasite, and multiplexed microbead-based immunoassay (Luminex) data obtained from the plasma of a representative subset of 31 P. vivax patients and 9 healthy donors (controls).

Parameters	Healthy donors (n = 36)	Symptomatic Pv patients (n = 79)	p-Value(Pv vs. control)
	Median [IQ 25–75]	Median [IQ 25–75]
Age	32 (23–49)	36 (28–45)	0.06
Parasitaemia (103/mL)	-	4.29 [1.86–6.62]
Parasitaemia (%)	-	0.76 [0.57–1.25]
Parasite load (copies 18S RNA/mL)	-	26,642 [9253-522,297]
PvLDH (O.D.)	-	0.18 [0.005–0.34]
Plasma biomarkers	Healthy donors (n = 9)	Symptomatic Pv patients (n = 31)	p-Value (Pv vs. control)
TNF-α (pg/mL)	17.2 [11.0–22.3]	38.4 [30.0–69.6]	<0.0001
IL-1α (pg/mL)	11.9 [10.0–19.5]	25.4 [19.8–33.5]	0.0004
IL-1β (pg/mL)	12.0 [8.0–12.8]	21.4 [14.5–27.6]	<0.0001
IL-6 (pg/mL)	3.0 [2.5–3.7]	33.4 [7.6–133.1]	<0.0001
IL-8 (pg/mL)	2.2 [0.6–2.4]	6.4 [2.7–19.9]	0.0005
IL-10 (pg/mL)	–*	314 [169–562]	–
G-CSF (pg/mL)	9.485 [9.485–9.485]	101.5 [33.49–239.6]	<0.0001
L-selectin (ng/mL)	326 [287–391]	481 [386–579]	0.0019
ICAM-1 (ng/mL)	323 [260–464]	634 [456–849]	0.0026
VCAM-1 (ng/mL)	819 [623–959]	2875 [1753–5108]	<0.0001
E-Selectin (ng/mL)	26.4 [22.5–33.7]	56.7 [41.5–74.1]	0.0001
P-selectin (ng/mL)	17.0 [15.4–20.6]	22.2 [17.6–25.7]	0.0621
Angiopoietin-1 (ng/mL)	0.4 [0.3–0.6]	0.5 [0.2–0.9]	0.8874
Angiopoietin-2 (ng/mL)	1.8 [1.5–2.1]	4.3 [2.7–5.3]	0.0003
Ang-2:Ang-1 ratio	4.2 [2.7–5.6]	12.14 [2.7–40.2]	0.03
VWF-A2 (pg/mL)	126 [120–150]	218 [199–277]	<0.0001
ADAMTS13 (ng/mL)	1110 [483–1740]	776 [572–1328]	0.5485
PAI-1 (pg/mL)	78.9 [62.4–96.4]	112 [69.3–242]	0.1541
CD40L (ng/mL)	0.5 [0.4–0.7]	1.0 [0.7–1.3]	0.0001
Syndecan-1 (ng/mL)	1.8 [1.6–2.4]	3.7 [2.9–6.0]	0.0003
IL-11 (ng/mL)	3.5 [2.9–4.3]	5.7 [4.7–6.4]	<0.0001
TPO (ng/mL)	2.0 [1.7–2.2]	3.0 [2.6–3.4]	<0.0001
CXCL4 (ng/mL)	0.8 [0.6–1.2]	1.4 [0.7–2.8]	0.1236
CXCL7 (ng/mL)	0.4 [0.4–0.5]	0.73 [0.4–1.7]	0.1958
SCF (pg/mL)	47.61 [37.34–89.34]	45.68 [36.22–61.39]	0.1594

PvLDH: P. vivax lactate dehydrogenase.

* = under detection limit.