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. 2021 Aug 26;118(35):e2109517118. doi: 10.1073/pnas.2109517118

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Copyright © 2021 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 3. — BRD9 inhibitor or degrader synergize with Dex to repress macrophage inflammatory responses. (A) GSEA enrichment plot showing the similarity between RNA-seq of LPS-induced, iBRD9/dBRD9 BMDM, and LPS-induced, Dex-repressed BMDM. (B) Heatmap of genes synergistically repressed or activated by iBRD9/dBRD9 and Dex in LPS-stimulated BMDM. (C) Enriched GO categories. (D) Heatmap of genes synergistically repressed or activated by dBRD9 and Dex in LPS+IFN-γ activated BMDM. (E) Enriched GO categories. (F) LISA analysis of potential enriched upstream regulator of LPS/LPS+IFN-γ induced, Dex-dBRD9 repressed genes.