Fig. 1.

Growth arrest and drug tolerance of NR Mtb under hypoxia is associated with metabolic remodeling. The effect of supplementing with SME alone (A) or in the presence of INH (B) on hypoxic Mtb viability. The effect of supplementing with PEP alone (C) or in the prescence of INH (D) on hypoxic Mtb viability. In B and D, day 0 indicated the moment after treatment with INH (at 18 h after treatment with either SME or PEP). Experiments were conducted in m7H9 containing 0.2% acetate. All values were the average of triplicates ± SEM and representative of at least two independent experiments. *P < 0.01 by Student’s t test.