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. 2021 Aug 27;118(35):e2101657118. doi: 10.1073/pnas.2101657118

Fig. 4.

Fig. 4.

Dual-mechanism inhibitors promote conformations of ER that are distinct from traditional single mechanism inhibitors. (A) Hierarchical clustering of MARCoNI FRET assay for interaction of full-length and WT ER with 154 peptides derived from nuclear receptor-interacting proteins and the indicated ligands. (B and C) MARCoNI Pearson correlations for 4OHT versus the indicated ligands. Fulvestrant (Fulv), GDC-0810 (GDC), or AZD9496 (AZD). r = Pearson correlation ligand versus 4OHT. (D) Hierarchical clustering of MARCONI data with ER-Y537S and the indicated ligands. (E) MARCoNI Pearson correlations for 4OHT versus [E]-C2-Pip (16) with the ER-Y537S. r = Pearson correlation (SI Appendix, Fig. S7).