Table 4.
Pharmacokinetic parameters of IPA in rats following p.o or i.v. administration.
| PK parameters | i.v. | p.o. | ||
|---|---|---|---|---|
| 5 (mg/kg) | 50 (mg/kg) | 100 (mg/kg) | 200 (mg/kg) | |
| C max1 (ng·mL−1) | 1740.1 ± 456.0 | 83.7 ± 32.9 | 296.4 ± 75.1 | 246.23 ± 94.4 |
| T max1 (h) | 0 ± 0 | 0.9 ± 0.1 | 0.6 ± 0.3 | 0.65 ± 0.1 |
| C max2 (ng·mL−1) | / | 61.6 ± 46.2 | 284.9 ± 183.4 | 286.9 ± 217.2 |
| T max 2 (h) | / | 6.4 ± 2.6 | 6.0 ± 1.4 | 8.80 ± 1.1 |
| AUC(0~24) | 744.7 ± 139.9 | 886.6 ± 636.2 | 2604.5 ± 1629.2 | 3184.7 ± 1721.0 |
| AUC(0~∞) (ng·h·mL−1) | 818.4 ± 66.2 | 923.3 ± 613.7 | 2643.9 ± 1640.0 | 3193.4 ± 1719.7 |
| CL/F (L·h−1) | 6.1 ± 0.5 | 70.3 ± 33.7 | 59.0 ± 44.0 | 79.8 ± 42.0 |
| t 1/2 (h) | 6.6 ± 5.9 | 10.4 ± 9.8 | 5.5 ± 2.3 | 3.6 ± 1.0 |
| MRT (h) | 1.4 ± 0.4 | 9.3 ± 1.3 | 7.6 ± 1.3 | 7.9 ± 0.5 |