Distribution of SARS-CoV-2-specific B cell receptor sequences across B cell subsets
(A) SARS-CoV-2 epitope-specific V(D)J rearranged B cell receptor sequences retrieved from CoVAbDab (Galson et al., 2020), IEDB (Vita et al., 2019), and (Ehling et al., 2021) were searched in the V(D)J single-cell data. Distribution of these B cell clones is shown across clusters, including proportion of SARS-CoV-2 epitope-specific clones with somatic hypermutation (SHM) per cluster.
(B) Isotype of SARS-CoV-2 epitope-specific clones.