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. 2021 Oct 23;24(11):103331. doi: 10.1016/j.isci.2021.103331

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Scatterplot and tripartite network of essential genes, and their predicted drugs and pathways, determined by in silico single-gene deletions on the infected lung models

(A) Scatterplot of essentiality and safety scores of the essential genes. Essentiality and safety scores correspond to the number of infected and healthy models, respectively, in which each gene is predicted to be essential. The y axis indicates the number of infected cell lines for which the gene is predicted to be essential, whereas the x axis indicates the number of control cell lines that are predicted to remain unharmed by the silencing of the target genes.

(B) Tripartite network of the drug-gene-pathway interactions of the essential genes: A network of the single repositioned drugs and their essential genes, predicted by in silico gene deletion, was built. The relationships between the essential genes and their pathways were mapped using Recon3D_01 subSystem. Genes, and their connected drugs, that don't have pathways in Recon3D_01 subSystems were discarded.