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. 2021 Oct 23;24(11):103331. doi: 10.1016/j.isci.2021.103331

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Pathway analysis of the essential genes in the two lung studies

Identification of the pathways harboring the identified essential genes using Enrichr and Recon3D_01 subSystem, and hence the most critical pathways for the viral survival and proliferation across cell type, severity level, and time after infection. On the x axis from the left to the right, are the conditions of both the severity study and the time-series lung studies, respectively (related to STAR Methods B). Conditions in the severity study were named as cell line + ACE2 vector (if exists) + MOI. Conditions in the second lung cell line were named as cell line + time point.

(A) Enrichr enrichment: The color code in (A) "Enrichment [%]" represents the number of enriched genes in this pathway divided by the overall number of genes in this pathway.

(B) Metabolic pathway analysis: The color code in (B) "Reactions per Pathway [%]" represents the number of enriched metabolic reactions in a pathway divided by the overall number of reactions in this pathway.