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. 2021 Oct 23;24(11):103331. doi: 10.1016/j.isci.2021.103331

Figure 5.

Figure 5

Tripartite network of the drug-gene-pathway interactions of the synergetic gene pairs determined by double gene deletion

Determination for the individual repositioned drugs for the synergistic gene pairs, and also mapping the relationships of the genes to pathways determined by Recon3D_01 subSystem.

(A) Tripartite network of the reduced list of double gene deletion drug pairs: Candidate gene pairs causing synergistic lethality were determined by double gene knockout (DKO) (related to STAR Methods A.2.3). Gene pairs for which both genes are targeted by the same drug were excluded from the candidate list for drug combinations and added to the list of single drugs. Genes, and their associated drugs, that are not present in Recon3D_01 were discarded.

(B) Tripartite network of single drugs targeting two genes that reduce biomass when knocked-out together: The gene pairs were determined by DKO (related to STAR Methods A.2.3). Only targets present in Recon3D_01 were included in the analysis.