Table IV.
SARS-Cov-2 memory B- and T-cell responses among SARS-CoV-2 IgG+, IgM+IgA−IgG−, and seronegative subjects
| Characteristic | IgG+ |
IgM+IgA−IgG− |
Seronegative |
P value† | |||
|---|---|---|---|---|---|---|---|
| N/n (%) | Median (IQR)∗ | n/N (%) | Median (IQR)∗ | n/N (%) | Median (IQR)∗ | ||
| B-cell response | 32/47 (68.1) | 50 (4-109) | 0/6 (0.0) | 0 (0-3) | 2/54 (3.7) | 0 (0-2) | <.0001/<.001 |
| T-cell response (any) | 27/49 (55.1) | NA | 3/7 (42.9) | NA | 9/52 (17.3) | NA | <.0001/NA |
| T-cell response S1 | 21/49 (42.9) | NA | 3/7 (42.9) | NA | 5/52 (9.6) | NA | .001/NA |
| IFN-γ | 16/49 (32.7) | 3 (0-11) | 1/7 (14.3) | 2 (2-5) | 1/52 (1.9) | 0 (0-1) | <.0001/<.001 |
| IL-2 | 14/49 (28.6) | 1 (0-11) | 3/7 (42.9) | 7 (0-30) | 4/52 (7.7) | 0 (0-0.5) | .008/.010 |
| IFN-γ/IL-2 | 7/49 (14.3) | 1 (0-3) | 1/7 (14.3) | 2 (0-3) | 0/52 (0.0) | 0 (0-0) | .018/.0001 |
| T-cell response S N M O | 26/49 (53.1) | NA | 3/7 (42.9) | NA | 7/52 (13.5) | NA | <.0001/NA |
| IFN-γ | 23/49 (44.9) | 9 (2-26) | 2/7 (28.6) | 2 (2-15) | 1/52 (1.9) | 0 (0-2) | <.0001/<.001 |
| IL-2 | 17/49 (34.7) | 1 (0-14) | 3/7 (42.9) | 6 (1-20) | 6/52 (11.5) | 0 (0-4.5) | .012/.028 |
| IFN-γ/IL-2 | 17/49 (34.7) | 3 (0-8) | 1/7 (14.2) | 1 (0-5) | 1/52 (1.9) | 0 (0-1) | <.0001/<.001 |
IQR, Interquartile range; NA, not applicable.
∗
Median number of positive cells.
†
Chi-square test/Kruskal-Wallis test.