Figure 2.

AP205-RBD elicited neutralizing antibodies in mice

(A and B) Neutralization titers (defined as half-maximal inhibitory concentrations) against pseudovirus (A) or live SARS-CoV-2 virus (B) in sera collected after the second immunization were presented for the indicated immunization groups. Symbols indicate data collected from individual mice. Bars indicate the geometric mean of each group. The number (n) of mice examined in each group was shown. A Kruskal-Wallis test was used to compare the four groups. There are significant differences among the four groups for both (A) and (B). Dunn’s multiple comparisons test was then used to compare between the AP205-RBD-immunized group and one of the other immunized groups, and the adjusted p value was used to indicate the statistical significance (∗∗p < 0.01, ∗∗∗p < 0.001).

(C) Pairwise correlations between anti-RBD IgG and neutralization titers (NTs) against the pseudovirus or NTs against live SARS-CoV-2 virus measured from the same set of serum samples are shown. Dots represent the data from individual mice, and colors indicate different immunization groups. The same raw data were used to generate Figures 1D, 2A, and 2B. Spearman’s correlation coefficient is shown.

See also Figure S2.