Figure 6.

AP205-RBD elicited neutralizing antibodies in non-human primates

(A) Time points for immunizations, serum collections, and viral challenge in macaques.

(B) Serum anti-RBD and anti-AP205 IgG from macaques immunized with PBS or AP205-RBD were examined at the indicated time points.

(C–F) Neutralization activity against the pseudovirus (C and D) or the live SARS-CoV-2 virus (E and F) in the sera collected after the second immunization was examined. Curve fitting was used to determine the half-maximal inhibitory concentrations (IC₅₀) (C and E), which were presented as the neutralization titers in (D) and (F). Symbols indicate data of individual animals, and bars indicate the geometric mean of each group. Mann-Whitney test was used for statistical analysis (∗p < 0.05).