Table 3.

Significant result from the interaction analyses of previously implicated SNPs with a cumulative pre- and perinatal adversity score in relation to lifetime tic severity

SNP	Position	Chromosome	Gene	Category	Initial sample		Replication sample
					F	P a	F	P a
rs6539267	106,785,554	12	POLR3B	GWAS TS	6.8	0.001*	0.43	0.65

SNP single-nucleotide polymorphism, GWAS genome-wide association study, TS Tourette syndrome

*Significant after correcting for multiple testing (P_all = 0.0014)

^aAnalyses were corrected for age, sex, and socioeconomic status