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. 2021 Oct 8;95(12):3651–3664. doi: 10.1007/s00204-021-03155-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — KMD Region Identified in AUC-External dose plot from Figure 8(a) of Slob et al. 2020. Figure 8 of Slob et al. 2020 showing the relationship between area under the blood concentration curve (AUC) for 2,4-D plotted against the base 10 logarithm of the dose administered to rats. The blue dashed line is an estimate of the slope of the relationship at doses below a log10-dose of approximately 1.6, across which the slope appears to be stable. Red dashed lines are estimates of the slope of the relationship in the dose range of log10-dose 1.6–2.0