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. 2021 Sep 10;88(6):961–971. doi: 10.1007/s00280-021-04349-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Effect of MTX and HPE administration on lipid levels of the different experimental groups for A total bilirubin, B cholesterol, and C triglycerides. Each value represents the mean ± SD for 10 animals per group. ***Highly significant in comparison with the control group at p < 0.001. **Significant in comparison with the control group at p < 0.01. ^aHighly significant in comparison with the MTX group at p < 0.001. ^bSignificant in comparison with the MTX group at p < 0.01