Table 1.

Histopathological scoring analysis in liver sections of all experimental groups. Severity of liver histological changes using scores on a scale of none (–), mild ( +), moderate (+ +), and severe (+ + +) damage

Histological scoring	Control (G1)	MTX (G2)	HPE (G3)	MTX plus HPE (G4)
Irregular architecture	−	+  +	−	+
Portal inflammation	−	+  +  +	−	−
Central vein dilation	−	+  +  +	−	−
Sinusoidal dilation	−	+  +	−	−
Leukocytic infiltration	−	+  +  +	−	−
Pyknotic nuclei	−	+  +	−	−
Cellular necrosis	−	+  +	−	−
Vacuolar degeneration	−	+	−	−
Portal vein dilation	−	+  +  +	−	−