Table 11.
Comet assays in presence of FPGa in the lung of female Wistar rats
| NVP dose | Ani-mal (number) | Indi-vidual viability (%) | Viability (%) (mean ± SD) |
Hedgehogs/100 cells (mean ± SD) | TI (%)b | TI (%) (mean ± SD) |
|---|---|---|---|---|---|---|
| 0 ppm | 25 | 99 | 99 ± 1 | 3 ± 2 | 8.8 | 8.7 ± 1 + .81 |
| 26 | 100 | 10.7 | ||||
| 27 | 100 | 7.9 | ||||
| 28 | 100 | 8.0 | ||||
| 29 | 100 | 10.6 | ||||
| 30 | 97 | 5.9 | ||||
| 5 ppm | 31 | 99 | 99 ± 1 | 3 ± 2 | 7.3 | 7.8 ± 1.30 |
| 32 | 99 | 8.6 | ||||
| 33 | 99 | 7.0 | ||||
| 34 | 99 | 6.8 | ||||
| 35 | 98 | 10.1 | ||||
| 36 | 98 | 7.1 | ||||
| 10 ppm | 37 | 98 | 98 ± 1 | 1 ± 1 | 8.7 | 7.2 ± 1.81 |
| 38 | 97 | 8.1 | ||||
| 39 | 99 | 7.9 | ||||
| 40 | 97 | 8.4 | ||||
| 41 | 99 | 6.0 | ||||
| 42 | 100 | 4.0 | ||||
| 20 ppm | 43 | 98 | 98 ± 1 | 3 ± 1 | 6.2 | 7.4 ± 2.90 |
| 44 | 98 | 8.6 | ||||
| 45 | 99 | 10.2 | ||||
| 46 | 95 | 2.3 | ||||
| 47 | 98 | 7.7 | ||||
| 48 | 98 | 9.7 |
aFPG, formamido pyrimidine DNA glycosylase
bMean of medians from 2 slides, each carrying 50 evaluated cells