Table 17.

Lauric acid hydroxylation^a

NVP dose	Animal (num-ber)	ω-hydroxylase (CYP4A-activity)			ω-1-hydroxylase (CYP2E1-activity)
		Peak surface	Enzyme activity individual	Enzyme activity group	Peak surface	Enzyme activity individual	Enzyme activity group
0 ppm	1	16,449	10,966	10,983 ± 2236	6737	4491	4512 ± 1050
	2	10,791	7194		4325	2883
	3	17,564	11,709		6828	4552
	4	15,737	10,491		6957	4638
	5	21,137	14,091		9280	6187
	6	17,170	11,447		6482	4321
20 ppm	19	27,314	20,495	14,727 ± 5456	9940	7458	5149 ± 2010
	20	28,341	20,593		10,040	7295
	21	15,814	10,543		5283	3522
	22	21,818	14,545		7513	5008
	23	23,109	15,406		7824	5216
	24	11,088	6779		3996	2393

Mean ± standard deviation; enzyme activity represented as peak surface/min/mg protein resulting from 0.075 mg submitted to HPLC analysis