Table 6.

Comet assays^a in the lung of male Wistar rats

NVP dose	Ani-mal (number)	Indi-vidual viability (%)	Viability (%) (mean ± SD)	Hedgehogs/100 cells (mean ± SD)	TI (%)b	TI (%) (mean ± SD)
0 ppm	1	97	98 ± 1	6 ± 3	1.2	1.2 ± 0.47
	2	99			1.0
	3	99			2.1
	4	99			0.8
	5	98			1.0
	6	98			0.9
5 ppm	7	98	98 ± 1	4 ± 3	1.9	1,1 ± 0.61
	8	97			1.8
	9	99			0.6
	10	99			0.7
	11	97			0.7
	12	100			0.8
10 ppm	13	99	98 ± 2	7 ± 5	5.7	1.8 ± 1.94
	14	99			1.3
	15	98			1.2
	16	99			0.7
	17	93			1.0
	18	99			1.1
20 ppm	19	100	99 ± 1	3 ± 1	0.4	0.6 ± 0.28
	20	100			0.9
	21	98			0.9
	22	97			0.6
	23	99			0.3
	24	100			0.4
EMSc (Positivecontrol)	49	99	99 ± 1	9 ± 4	20.7	19.3 ± 5.15
	50	99			14.6
	51	99			26.5
	52	100			13.1
	53	99			23.3
	54	98			17.8

^aconventional assays (no FPG added)

^bmean of medians from 2 slides, each carrying 50 evaluated cells

^cEMS, ethyl methanesulfonate