Table 1.

Therapies targeting NETs in wound healing.

Mechanism	Drug/Method	Administration	Wound healing outcome	Ref.
PAD4 inhibitor	PAD4-/- in normoglycemic wound		No H3cit was detected; wounds were healed 80% on day 14 and 25% in WT controls	[7]
	PAD4-/- in diabetic wound		Healed >35% faster, wound area reduced by 28%	[7]
	CI-amidine	10 mg/kg i.v.	H3cit and wound aera decreased	[12]
	Tripeptide (Thr-Asp-F-amidine)	Topically	Wound closure and re-epithelialization accelerated	[98]
DNase 1	Pulmozyme	10 mg/kg i.p.	Superior scar scores and wound closure time	[96]
	Dornase alfa	10 μg i.v. 50 μg i.p.	Wound area reduced by >20% and re-epithelialization by 75%	[7]
	Deoxyribonuclease I from bovine pancreas	Topically	Inflammatory response reduced; re-epithelialization and healing accelerated	[84]
ROS production and MAPK activation	Na2S	50 μmol/kg i.p.	NETs reduced; NE activity decreased; wound healing accelerated	[105]
NET formation	GnRH antagonist		Wound size reduced	[89]
	LRG-1 ablation		Wound size reduced	[87]
PKC β inhibitor	Metformin	Orally	NETs reduced	[91]
	Ruboxistaurin	Orally	Wound closure accelerated, nearly complete re-epithelialization by 14 days	[88]
NLRP3 inflammasome-NET axis	Recombinant mouse MFG-E8	500 ng/ml	NETs reduced, NETs-primed NLRP3 inflammasome was inhibited	[86]
NET structure	Clarithromycin	2 μg/ml for 210 min	LL-37 increased, fibroblasts activated, collagen increased	[64]