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. 2021 Oct 22;12:6151. doi: 10.1038/s41467-021-26390-w

Fig. 5. Oca6 acts upstream and Rob1 acts downstream of Yak1 to enable C. albicans filamentation.

Fig. 5

a Deletion of YAK1 in Lineage 1 blocked C. albicans filamentation in response to high temperature. Strains of C. albicans were grown in YPD at 42 °C for 6 h in the absence or presence 1-ABC, as indicated. Data represent two biological replicates. b Deletion of YAK1 in Lineage 2 did not affect the mutant phenotype and C. albicans continued to filament in the presence of 1-ABC. Strains of C. albicans were grown as described in (a). Data represent two biological replicates. c Model depicting proposed mechanisms by which Yak1, Oca6, and Rob1 interact in regulating C. albicans hyphal morphogenesis in the absence or presence of 1-ABC. Created with BioRender.com.