Table 2.
Gene set enrichment analyses using the target genes of the miRNAs.
| Gene set | Group | Up-/Down -regulated miRNAs | Pathway/GO term | No. of genes (Hits/Total) | p-value | FDRa |
|---|---|---|---|---|---|---|
| KEGG | VaD | Up | Ras signaling pathway (KEGG: hsa04014) | 17/232 | 2.6 × 10–5 | 0.0083 |
| GO | AD | Up | Nucleobase-containing compound transport (GO:0015931) | 4/175 | 3.5 × 10–5 | 0.029 |
| Up | RNA export from nucleus (GO:0006405) | 3/86 | 1.1 × 10–4 | 0.046 | ||
| DLB | Up | Homophilic cell adhesion (GO:0007156) | 17/139 | 6.5 × 10–8 | 5.3 × 10–5 | |
| Up | Cell–cell adhesion (GO:0098609) | 30/461 | 1.6 × 10–6 | 6.6 × 10–4 |
aFDR false discovery rate.