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. 2021 Oct 22;11:20920. doi: 10.1038/s41598-021-00392-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Dose-dependent response to repeated cisplatin induction. (a) Experimental scheme. Cisplatin was injected repeatedly at a different dose. (b) Dose-dependent BUN increase in repeated cisplatin-induced nephropathy. (c) Dose-dependent kidney weight reduction in repeated cisplatin-induced nephropathy. (d) Histological analysis of the kidney. PAS staining, Masson’s trichrome, and immunostaining of megalin and kim-1. (e, f, g) Quantification of the tubular injury score, fibrosis score, and the number of kim-1 + tubules. (h) Quantitative PCR of whole kidneys for the representative markers of mature tubules (Lrp2), fibrosis (Col1a1 and Tgfb1), and inflammation (Tnfa, Adgre1, and Ccl2). Data are the mean ± SE. *P < 0.05, †P < 0.05 vs other groups. Scale bar = 100 μm.