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. 2021 Oct 22;11:20880. doi: 10.1038/s41598-021-00306-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Accelerated myotube formation with ZSWIM8 knockdown. (A) Growing (day 0) or differentiated (day 3) control or ZSWIM8-knockdown (#2 or #6) C2C12 cells were immunostained with an anti-myosin heavy chain (MHC) antibody. Nuclei were stained with DAPI. Scale bar, 20 μm. MHC-positive and multinucleated cells were considered myotubes. (B) Quantification of fusion indexes of (A). The number of nuclei inside MHC-positive myotubes was divided by total nuclei in different fields. Data represent the mean ± SD; n = 150. Asterisk indicates statistical significance compared to the control sample.