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. 2021 Oct 22;11:20871. doi: 10.1038/s41598-021-00150-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Dual inhibition of CDK1 and HSP90 robustly reduces the level of HIF1α. (Α) HCT116, (C) HCT116 p53^−/− cells or (D) other colorectal cell lines were treated with control or CDK1 siRNA for 48 h, followed by treatment with DMSO or geldanamycin (2 μM) under hypoxia (0.5% O₂) for 6 h. (B) Cells were treated with Ro-3306, geldanamycin, or the combination of both for 6 h under hypoxia.