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. 2021 Oct 22;11:20871. doi: 10.1038/s41598-021-00150-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Ro-3306 and geldanamycin synergistically inhibit HCT116 cell viability through induction of apoptosis. (A) In normoxia or (B) hypoxia (0.5% O₂), cells were treated with Ro-3306 and geldanamycin at the indicated concentrations for (A) 48 or (B) 72 h. (C) Sub-G1 analysis by propidium iodide staining and flow cytometry of cells treated with Ro-3306 (10 μM) and geldanamycin (1 μM) under normoxia for 48 h or under hypoxia for 72 h. (D) Western blot of PARP cleavage in cells treated with Ro-3306 or geldanamycin or both. (Ε) CellTiter-Glo analysis of cell viability in HCT116 Bax^-/- cells treated at indicated concentrations under normoxia for 48 h. Statistical analysis was performed using one-way ANOVA supplemented with Dunnett test. Mean ± SD was shown. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.