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. 2021 Oct 22;11:20871. doi: 10.1038/s41598-021-00150-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Combination CDK1 and HSP90 inhibitor treatment inhibits colony formation and migration in HCT116 cells. (A) In normoxia or (B) In hypoxia (0.5% O₂), HCT116 cells were treated with the indicated combination treatments for 72 h. Drug-containing media was replaced with regular culture media, and cells were allowed to grow and form colonies for 1 week. (C) Scratch assay and (D) Quantification for HCT116 cells under normoxia for 48 h. Gap ratio refers to the ratio of gap width at 48 h versus at 0 h. Cells were treated with Z-VAD caspase inhibitor to prevent cell death. (R: Ro-3306; G: geldanamycin.) n = 3. Statistical analysis was performed using one-way ANOVA supplemented with Dunnett test. Mean ± SD was shown. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.