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. 2021 Oct 22;11:20871. doi: 10.1038/s41598-021-00150-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Rb-deficiency does not affect the combinatorial inhibition of HIF1α expression and cell viability. (A, B) Combination treatment with abemaciclib and TAS116 synergistically inhibits cell viability in Saos2 osteosarcoma cells at 72 h under (A) normoxia and (B) hypoxia (0.5% O₂). (C) SW480 cells were incubated with Rb-targeting siRNA for 48 h and subsequently treated with 1 μM abemaciclib and/or 0.5 μM TAS116 for 6 h in hypoxia (0.5% O₂). (D) Knockdown of Rb does not affect HIF1α inhibition by combination drug treatment with TAS116 and abemaciclib in MCF7 breast cancer cells. (E, F) SW480 cells were treated with (E) mock or (F) Rb-targeting siRNA for 48 h and subsequently treated with indicated combinations under normoxia (upper) or 0.5% O₂ hypoxia (lower).