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. 2021 Oct 22;4:1213. doi: 10.1038/s42003-021-02719-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Dimension reduction and clustering (PCA-UMAP) in all cells of brain organoids generated by orbital mixing and vertical mixing. Three organoids were generated by orbital mixing: Org1, Org2, and Org3; three organoids were generated by vertical mixing: Org4, Org5, and Org6. b Major markers for neurons and glial cells were displayed in each panel. Neural progenitor markers: PAX6 and SOX2; neuronal markers: FOXG1, MAP2, and NCAM1; deep cortical layer markers: BCL11B (or CTIP2), TBR1, and SOX5; upper cortical layer markers: CUX2 and SATB2; glutamatergic neuron markers: GRIA2 and SNAP25; GABAergic neuron markers: GAD2, DLX1, and DLX5; astrocyte markers: AQP4 and GFAP; oligodendrocyte markers: OLIG1 and OLIG2; microglia marker: CX3CR1.