Table 1.

Clinical and demographics values per diagnostic group. Mean ± standard deviation were reported.

	CTRL (26)	PSP-wvd (54)	PSP-vd (33)	iNPH (23)	P-value	Post-hoc
Age	72.4 ± 4.5	70.7 ± 6.0	74.9 ± 9.5	74.5 ± 7.9	0.20a	N.Ab
Female, n	7	25	8	2	N.A.	iNPH ≠ PSP-wvdc
Age at onset	N.A.	65.7 ± 6.2	67.4 ± 7.4	70.4 ± 8.4	<0.001a	iNPH > PSP-wvdb
Disease duration	N.A.	4.87 ± 3.0	5.73 ± 3.2	4.00 ± 3.7	0.24a	N.A.b
UPDRS-III	N.A.	37.9 ± 9.3	40.4 ± 7.1	13.1 ± 11.1	<0.001a	iNPH < PSP-wvd, PSP-vde
UPDRS gait (item 29)	N.A.	2.65 ± 0.9	2.91 ± 0.9	1.89 ± 1.3	0.02a	iNPH < PSP-wvd, PSP-vdb
iNPHGS	N.A.	N.A.	N.A.	5.0 ± 3.2	N.A.	N.A.
MMSE	27.1 ± 1.2	22.2 ± 5.8	22.1 ± 5.7	21.9 ± 7.3	0.012d	CTRL > PSP-wvd, PSP-vd, iNPHe
EI	0.262 ± 0.05	0.267 ± 0.03	0.327 ± 0.01	0.379 ± 0.03	<0.001d	CTRL < PSP-vd, iNPHe PSP-wvd < PSP-vd, iNPHe PSP-vd < iNPHe
VVf	0.002 ± 0.004	0.016 ± 0.01	0.030 ± 0.01	0.062 ± 0.03	<0.001d	CTRL < PSP-vd, iNPHe PSP-wvd < PSP-vde iNPH > PSP-wvd, PSP-vde
MRHI	0.50 ± 0.02	0.51 ± 0.02	0.54 ± 0.02	0.61 ± 0.02	<0.001d	CTRL < PSP-vd, iNPHe PSP-wvd < PSP-vd, iNPHe PSP-vd < iNPHe

Abbreviations: CTRL = controls; PSP-wvd = Progressive Supranuclear Palsy without ventricular dilatation; PSP-vd = Progressive Supranuclear Palsy with ventricular dilatation; iNPH = Normal Pressure Hydrocephalus; UPDRS-III = Unified Parkinson’s Disease Rating Scale – pars III, MMSE = Mini-Mental State Examination, iNPHGS = iNPH grading scale; EI = Evans Index; VV = Ventricle Volume; N.A. = Not applicable.

^aANOVA p-value, significant at < 0.05.

^bPost-Hoc of ANOVA corrected for multiple comparisons with Tukey’s, significant at < 0.05.

^cPairwise Chi-squared, significant at < 0.05.

^dANCOVA with age and gender in covariates, significant at < 0.05.

^ePost-Hoc of ANCOVA with age and gender in covariates, corrected for multiple comparisons with Tukey’s HSD test, significant at < 0.05.

^fNormalized for the total intracranial volume.