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. 2021 Jul 17;12(5):1599–1615. doi: 10.1016/j.jcmgh.2021.07.002

Figure 2.

Figure 2

Hepatocyte-specific DGAT1 knockout exacerbates alcohol-induced liver injury in mice. Floxed and DGAT1Δhep mice were PF or AF for 8 weeks. (A) Analysis of serum ALT and AST levels (n = 5/group). (B) H&E staining of liver tissue sections (n = 5/group). Scale bars, 20 μm. Arrowheads: hepatocyte degeneration. Arrows: hepatic lipid droplets. CV, central vein. (C) Immunohistochemistry analysis of TUNEL on liver tissue sections (n = 5/group). Scale bars: 50 μm. Arrow: TUNEL positive cells. (D) Immunohistochemistry staining of 4-HNE on liver tissue sections (n = 5/group). Scale bars, 20 μm. (E) Cxcl1 and Ly6g mRNA expression (n = 5/group). (F) Immunofluorescence staining of hepatic MPO positive cells (red) (n = 5/group). Scale bars, 20 μm. Data are shown as means ± SD. ∗P < .05.