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. 2021 Jul 17;12(5):1599–1615. doi: 10.1016/j.jcmgh.2021.07.002

Figure 7.

Figure 7

Hepatocyte-specific LAMP2 overexpression attenuates alcohol-induced lipid accumulation and liver injury in mice. C57BL/6J mice with or without hepatocyte-specific LAMP2 gene delivery were fed control or alcohol liquid diet for 8 weeks. (A) Analysis of hepatic FFA and TG contents (n = 4/group). (B) BODIPY 493/503 staining of neutral lipids in mouse liver (n = 4/group). Scale bars, 20 μm. (C) Analysis of serum ALT and AST levels (n = 4/group). (D) H&E staining of liver tissue sections (n = 4/group). Arrowheads: hepatocyte degeneration. Arrows: hepatic lipid droplets. Scale bars, 20 μm. (E) Cxcl1 and Ly6g mRNA expression (n = 4/group). (F) Immunofluorescence staining of hepatic MPO positive cells (red) (n = 4/group). Scale bars, 20 μm. Data are shown as means ± SD. ∗P < .05. CV, central vein; OE, overexpression.