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. 2021 Oct 18;16:7071–7090. doi: 10.2147/IJN.S325448

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© 2021 Zhu et al.

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The cross-talk between MVs and exosomes. MVs and exosomes are released from many cells, including tumor cells, CAFs, and TAMs. They can secret MVs-containing EGFR and exosomes-containing EGFR, which influence tumor progression, for example, transforming normal cells into tumor cells, promoting angiogenesis and metastasis. Moreover, normal cells, which take up MVs and exosomes can increase the growth and survival of tumor cells by activating the MAPK/AKT pathway.

Abbreviations: CAFs, cancer-associated fibroblasts; TAMs, tumor-associated macrophages; EGFR, epidermal growth factor receptor.