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. Author manuscript; available in PMC: 2021 Oct 23.
Published in final edited form as: Cardiovasc Eng Technol. 2021 Jan 20;12(1):114–125. doi: 10.1007/s13239-021-00518-x

FIGURE 5.

FIGURE 5.

Efficient in vivo ICAM2 knockdown in the endothelium when siICAM2 was delivered using C6-KH polymer. (a) siICAM2-C6-KH and siCON-C6-KH were injected at 2 mg/kg in mice. Two days post-injection, endothelial-enriched (intima) and SMC-enriched fraction (leftover) RNAs were prepared and analyzed by qPCR for gene expression. (b) As a quality control, expression of markers of ECs (PECAM-1), medial SMCs (SM22a), and leukocytes (CD45) were determined, whereas (c) ICAM2 expression was analyzed by RT-qPCR. n = 5, mean ± SEM; ***p < 0.001.