Table 2.
Pulmonary function and 6MWT of surviving HCWs
| Characteristics | All | Group (n = 303) | ||
|---|---|---|---|---|
| HCWs with mild/moderate illness (n = 113) | HCWs with critical/severe illness (n = 190) | p value | ||
| Age, median (IQR), years | 39.00 (33.00–48.00) | 38.00 (31.00–46.00) | 39.00 (34.00–49.00) | 0.0476 |
| Sex | ||||
| Female, n (%) | 244 (80.53) | 91 (80.53) | 153 (80.53) | 0.9992 |
| BMI, median (IQR), kg/m2 | 23.44 (21.30–25.71) | 22.72 (20.96–24.99) | 24.00 (21.48–25.97) | 0.0093 |
| Spirometry, median (IQR) | ||||
| FEV1 (l), % predicted | 98.00 (89.80–106.00) | 97.90 (90.20–105.30) | 98.00 (89.60–106.00) | 0.9099 |
| < 80% pred, n/N (%) | 23 (7.59) | 11 (9.73) | 12 (6.32) | 0.2772 |
| VCmax (l), % predicted | 104.90 (97.70–112.80) | 105.10 (96.20–111.40) | 104.90 (97.90–113.60) | 0.4297 |
| FVC (l), % predicted | 106.70 (99.00–115.40) | 106.50 (97.90–114.40) | 107.05 (99.40–115.70) | 0.2603 |
| < 80% pred, n/N (%) | 7 (2.31) | 4 (3.54) | 3 (1.58) | 0.2719 |
| FEV1/FVC, % | 77.90 (74.46–81.69) | 78.73 (74.30–81.89) | 77.53 (74.56–81.43) | 0.191 |
| < 70%, n/N (%) | 24 (7.92) | 9 (7.96) | 15 (7.89) | 0.9826 |
| FEV1/VCmax, % | 77.58 (74.03–81.33) | 77.97 (74.30–81.57) | 77.06 (73.88–80.89) | 0.1456 |
| PEF (l/s), % predicted | 104.90 (95.10–114.50) | 104.30 (93.80–110.20) | 105.60 (95.70–116.10) | 0.0252 |
| MEF75 (l/s), % predicted | 99.60 (85.70–113.50) | 98.70 (84.10–110.80) | 100.55 (86.00–113.70) | 0.4874 |
| < 65% pred, n/N (%) | 14 (4.62) | 3 (2.65) | 11 (5.79) | 0.2088 |
| MEF50 (l/s), % predicted | 71.90 (59.90–86.50) | 70.90 (60.60–86.50) | 72.25 (59.00–86.00) | 0.8654 |
| < 65% pred, n/N (%) | 113(37.29) | 44(38.94) | 69 (36.32) | 0.6481 |
| MEF25 (l/s), % predicted | 49.40 (38.20–62.20) | 53.70 (40.40–63.00) | 47.80 (37.30–61.80) | 0.0887 |
| Lung volume, median (IQR) | ||||
| TLC (l) % predicted | 96.70 (91.00–103.10) | 97.10 (91.10–103.20) | 96.65 (90.90–102.90) | 0.8388 |
| < 80% pred, n/N (%) | 16 (5.28) | 6 (5.31) | 10 (5.26) | 0.986 |
| RV (l) % predicted | 95.50 (84.60–105.60) | 98.30 (86.30–108.70) | 93.65 (83.90–103.20) | 0.0632 |
| < 65% pred, n/N (%) | 8 (2.64) | 3 (2.65) | 5 (2.63) | 0.9902 |
| FRC (l) % predicted | 95.15 (83.30–110.40) | 102.60 (86.90–112.40) | 93.00 (82.50–107.10) | 0.005 |
| RV/TLC, % | 31.34 (27.90–34.57) | 31.61 (27.37–34.99) | 31.26 (27.92–34.48) | 0.8009 |
| FRC/TLC, % | 53.73 (47.96–59.48) | 55.42 (49.91–62.09) | 52.58 (47.19–58.19) | 0.0007 |
| Diffusion capacity (n = 200), median (IQR) | ||||
| DLCO, mmol/min/kPa | 7.16 (6.39–8.42) | 7.05 (6.34–8.35) | 7.20 (6.43–8.43) | 0.8478 |
| DLCO% predicted | 84.60 (76.90–95.00) | 84.20 (76.30–94.60) | 84.80 (77.60–95.10) | 0.5984 |
| < 80% pred, n/N (%) | 100 (43.48) | 41 (47.67) | 59 (40.97) | 0.3212 |
| DLCO/VA, mmol/min/kPa/l | 1.57 1.42–1.73) | 1.53 (1.42–1.71) | 1.58 (1.42–1.75) | 0.9874 |
| DLCO/VA% predicted | 91.40 (81.50–100.40) | 90.70 (81.00–98.10) | 91.80 (81.70–101.00) | 0.3789 |
| < 80% pred, n/N (%) | 58 (29.15) | 23 (30.67) | 35 (28.23) | 0.7135 |
| Distance walked in 6 min, median (IQR), m | 555.00 (516.00–591.00) | 564.00 (525.00–603.00) | 549.50 (514.00–582.00) | 0.0435 |
| Percentage of predicted value, % | 87.00 (81.00–94.00) | 86.00 (81.00–94.00) | 87.00 (81.00–94.00) | 0.8173 |
| Less than lower limit of the normal range | 58 (19.4) | 23 (20.4) | 35 (18.8) | 0.8610 |
Data are presented as median (interquartile range, IQR) for continuous variables and n (%) for categorical variables. Kruskal-Wallis (K-W) test was used for continuous variables and chi-square test or Fisher’s exact test for all categorical variables. DLCO was measured through single-breath method
HCWs health care workers, IQR interquartile range, BMI body mass index, FEV1 forced expiratory volume in 1 s, VC vital capacity, FVC forced vital capacity, PEF peak expiratory flow, MEF maximal expiratory flow, TLC total lung capacity, RV residual volume, FRC functional residual capacity, SB single-breath method, DLCO diffusing capacity of the lung for carbon monoxide, VA alveolar ventilation