Table 2.

Generalized additive models of the relationship between longitudinal PACC scores and total sleep time, sleep efficiency, NREM stage 2 and stage 3 and REM sleep

Generalized additive models
	Total sleep time		Sleep efficiency		NREM stages 2 and 3		REM
Spline fit	EDF		EDF		EDF		EDF
Sleep parameter	2.377***		2.808**		2.6100674***		1.6478***
Age at PACC	2.836***		2.821***		2.8406516***		2.7936***
Participant ID	1.118 × 10−3		9.09 × 10−2		4.752 × 10−4		0.2533
Covariate	Estimate	95% CI	Estimate	95% CI	Estimate	95% CI	Estimate	95% CI
CDR	−1.592***	−1.903, −1.281	−1.551***	−1.880, −1.222	−1.589***	−1.913, −1.266	−1.423***	−1.744, −1.101
CSF t-tau/amyloid-β42	−1.171***	−1.500, −0.843	−1.047***	−1.386, −0.708	−1.140***	−1.476, −0.804	−1.108***	−1.445, −0.770
Age at sleep study	0.038***	0.022, 0.055	0.025**	0.008, 0.042	0.037***	0.019, 0.054	0.026**	0.009, 0.042
APOE ε4+	0.146*	0.027, 0.266	0.135*	0.011, 0.258	0.167**	0.048, 0.287	0.179**	0.059, 0.299
Sex (male effect)	−0.236***	−0.343, −0.129	−0.181**	−0.290, −0.073	−0.177**	−0.288, −0.066	−0.231***	−0.338, −0.123
Education (years)	0.006	−0.018, 0.030	0.012	−0.014, 0.038	0.007	−0.018, 0.032	0.008	−0.017, 0.033
Intercept	−2.600***	−3.938, −1.261	−1.593*	−3.023, −0.163	−2.537***	−3.927, −1.147	−1.658*	−3.033, −0.284

n = 100; dependent variable = PACC. EDF = effective degrees of freedom.

^* P < 0.05, **P < 0.01, ***P < 0.001.