Table 3.
Summary of ocular insert patents studies (2011–2021).
| Insert Base | Targeted Diseases | Model Drug Used for Study | Applicant /Manufacturer/Assignee | Patent Number | Publication Date | Reference |
|---|---|---|---|---|---|---|
| Biodegradable, hydrophobic polymer | Tissue regeneration, glaucoma, infections on eye surface (all are possible) | Travoprost | Integral Biosystems LLC | AU 2019250153 A1 | 31 October 2019 | [75] |
| Biodegradable, hydrophobic, and/or amphiphilic polymer | Eye infections | Azithromycin | Zewail City of Science and Technology, Egypt | GB 2570113 A | 17 July 2019 | [76] |
| Hydrophilic, biodegradable, bioabsorbable, or bioerodible polymer | Glaucoma | Timolol maleate | Valeant International (Barbados) SRL | US2012215184A1 | 23 August 2012 | [77] |
| Thermoplastic polymer such as acrylonitrile butadiene styrene and ethylene-vinyl acetate | Glaucoma | Bimatoprost | ForSight VISION5 Inc. (US) | US2016022695A1 | 28 January 2016 | [78] |
| Polyvinyl-alcohol (PVA) | Bacterial infections (tuberculosis (TB)) | Rifampicin | Tongling Wutongshu Agricultural Dev. Co. Ltd. | CN104116722A | 29 October 2014 | [79] |
| Polymer such as poly-lactic/glycolic acid | Ocular inflammation associated with inflammatory diseases or following ocular surgery | Steroids | Interface Biologics Inc. (CA) | WO2019148291A1 | 08 August 2019 | [80] |
| Arylborono-containing hydrophilic copolymer | Anterior and posterior segment diseases | Optional | Alcon Inc. (CH) | US2021077385A1 | 18 March 2021 | [81] |
| Hydroxypropyl methylcellulose, polyvinylpyrrolidone, sodium carboxymethyl cellulose, and gelatin | Myopia | Atropine sulfate | Univ. Shenyang Pharmaceutical | CN111358771A | 07 July 2020 | [82] |
| Hydroxypropylcellulose and polyethylene oxide block copolymer | Glaucoma | Timolol maleate | Univ. Witwatersrand JHB (ZA) | WO2014041485A1 | 20 March 2014 | [83] |
| Thermoplastic polymer such as acrylonitrile butadiene styrene and thermosetting polymer such as silicone and polyesters | Glaucoma | Bimatoprost | ForSight VISION5 Inc. (US) | US2016296532A1 | 13 October 2016 | [84] |
| Polycaprolactone/polyethelyneglycol | Bacterial infections | Moxifloxacin | Univ. De Coimbra (PT) | WO2017137934A1 | 17 August 2017 | [85] |
| Poly-vinyl-alcohol | Fungal infections | Voriconazole | Univ. Zhejiang | CN105726517A | 06 July 2016 | [86] |
| Hyaluronic acid, polyvinyl-pyrrolidone, hydroxypropyl guar, and polyethyleneglycol | Dry eye | - | Alcon Inc. (CH) | WO2021116907A1 WO2020222195A1 US2021169781A1 | 17 June 2021 05 November 2020 10 June 2021 |
[87,88,89] |