Figure 1.

Screening of TAR RNA-targeting compounds. (A) Complex of acetylpromazine with TAR RNA (PDB ID: 1LVJ). (B) High-throughput screening for one round of HIV-1 infection. HIV-1-LUC-G infected CEM T cells were seeded in 96-well plates and treated with 10 μM concentration of compounds. DMSO represents 100% (blue) and percentage of inhibition was calculated for each compound. In red, compounds are shown that achieved more than 60% inhibition.