Figure 6.

ASTX treatment restores the levels of Nrf2, antioxidant enzymes, and circulating lymphocytes in STZ-induced diabetic mice. (A) Expression level of Nrf2 in the region of upper molars of mice groups were determined by IHC 60 days after hyperglycemia induction (200× magnification). Bar = 100 μm. (B) The activities of SOD and catalase in blood serum of mice groups were examined using their specific assay kits (n = 5). (C) Circulating levels of lymphocytes and RBC in mice groups were calculated using a blood cell counter (n = 5). The enzyme activities and blood cell numbers were checked 60 days after hyperglycemia induction. ** p < 0.01 and *** p < 0.001 vs. control group; ^# p < 0.05 and ^### p < 0.001 vs. STZ group.