Table 2.

Transcription factors or xenobiotic chemicals that regulate SLC13A5 gene expression.

		Species	Tissue	Effect a	Reference
	PXR	Human	Human primary hepatocytes	+	[25]
	AhR	Rat	Rat primary hepatocytes	+	[24]
Transcription Factor		Mouse	Mouse primary hepatocytes	+
	CREB	Rat	Rat primary hepatocytes	+	[72]
	STAT3	Human	Human primary hepatocytes	+	[26]
	Glucagon	Rat	Rat primary hepatocytes	+	[72]
Hormone or Cytokine	IL-6	Human	Human primary hepatocytes	+	[26]
		Mouse	Mouse liver	+
	RIF	Human	Human primary hepatocytes	+	[25]
	TCDD	Rat	Rat primary hepatocytes	+	[24]
	3MC	Rat	Rat primary hepatocytes	+	[24]
	BaP	Rat	Rat primary hepatocytes	+	[24]
		Mouse	Mouse primary hepatocytes	+
Chemicals or Others	Metformin	Human	HepG2 cells	−	[75]
	AICAR	Human	HepG2 cells	−	[75]
	Phenobarbital	Rat	Rat primary hepatocytes	+	[24]
	Bisphenol-A	Mouse	Mouse liver	−	[95]
	CTPI-2	Mouse	Mouse liver	+	[96]
	LPS	Human	Human non-parenchymal cells (including Kupffer cells) were co-cultivated with human primary hepatocytes	+	[26]
	6-Bnz-cAMP	Rat	Rat primary hepatocytes	+	[72]

^a +, induction of the SLC13A5 gene; −, repression of the SLC13A5 gene.