Figure 8.

Scheme of nucleotide exchange under steady state during actin polymerization. During the steady state phase of polymerization, ADP–actin complexes dissociate from the pointed end (-) of the filamentous actin. This is followed by nucleotide exchange (from ADP to ATP) and, consequently, ATP–actin associates mainly at the barbed end (+). ATP hydrolysis allows the translocation of subunits between the ends of the filament [45]. SETD3 is found to promote actin polymerization through H73 methylation [18].