. 2021 Oct 2;11(10):1040. doi: 10.3390/life11101040

Table 1.

Summary of the most important reported functions of SETD3 and its association with cell signaling pathways.

Process	SETD3 Activity	Proposed Functions	References
Actin polymerization	Methylation of H73 in β-actin	Stabilization of actin monomers	[17,18]
Actin polymerization	Methylation of H73 in β-actin	Promoting actin polymerization	[17,18]
Enterovirus pathogenesis	Unknown	Supporting viral genome replication	[63]
Enterovirus pathogenesis	Unknown	Interaction with viral protease 2A	[63]
Epigenetic regulation of chromatin	Methylation of core histones, plausibly H3	Regulation of gene expression	[25,26,44]
Response to hypoxia conditions	Methylation of FoxM1	Increasing expression of VEGF and promotion of angiogenesis	[49]
Carcinogenesis	Unknown	Regulation of cancer development and progression	[44,49,57,66,67,68,70,71,72,73,74,75]