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. 2021 Sep 23;13(10):1547. doi: 10.3390/pharmaceutics13101547

Figure 3.

Figure 3

EV-ZnPc effect on normal and tumor cells after PDT in vitro. (a) MC38 cells were incubated with ZnPc alone or EV-ZnPc cells prior to evaluation of dark toxicity (DT) and PDT-induced cytotoxicity by flow cytometry using Annexin-V/DAPI staining. PDT efficacy was evaluated in RAW, MC38, and D1DCs cells in (b) normal culture models and co-cultures of (c) D1DCs + MC38 and (d) RAW + MC38 cells. CFP and CD11b/c were used to distinguish the uptake between tumor cells and D1DCs or tumor cells and macrophages. Data are means ± SEM (n = 3). **** p < 0.0001; ** p < 0.01; * p < 0.05.