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. 2021 Oct 15;22(20):11109. doi: 10.3390/ijms222011109

Figure 3.

Figure 3

Regulatory effects of Rut on phospholipase Cγ2 (PLCγ2) and protein kinase C (PKC) activation in platelets. Washed platelets were preincubated with 0.1% DMSO or Rut (2.5 and 5 µM) and subsequently treated with collagen (1 µg/mL) or phorbol 12,13-dibutyrate (PDBu, 150 nM) to stimulate either (A) PLCγ2, (B) PKC activation (p-p47), or (C) platelet aggregation. Data are presented as the mean ± standard error of the mean (n = 4). *** p <0.001 compared with the resting platelets; # p < 0.05, ## p < 0.01, and ### p < 0.001 compared with the 0.1% DMSO-treated group. Profiles in (C) are representative of four independent experiments.