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. 2021 Oct 15;22(20):11109. doi: 10.3390/ijms222011109

Figure 4.

Figure 4

Regulatory characteristics of Rut on mitogen-activated protein kinase (MAPK) phosphorylation in platelets. Washed platelets were preincubated with 0.1% DMSO or Rut (2.5 and 5 µM) and then treated with collagen (1 μg/mL) for immunoblotting (A) ERK1/2, (B) JNK1/2, and (C) p38 MAPK phosphorylation. Data are expressed as the mean ± standard error of the mean (n = 4). *** p < 0.001 compared with the resting control; ## p < 0.01 and ### p < 0.001 compared with the 0.1% DMSO-treated group.