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. 2021 Oct 16;13(10):1708. doi: 10.3390/pharmaceutics13101708

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Pharmacokinetic/pharmacodynamic model. C°: concentration of palbociclib; CIRC: compartment corresponding to the circulating neutrophils; CIRC₀: ANC at time 0 in CIRC compartment; CIRC_t: ANC at time t in CIRC compartment; Cl/F: palbociclib apparent clearance; E_D: drug effect; γ: feedback mechanism; k_a: palbociclib absorption constant; k_circ: rate of elimination of neutrophils from the systemic circulation; k_prol: rate of stem cell proliferation; k_tr: maturation rate; MTT: mean transit time; PROL: proliferation compartment; Slope: sensitivity to palbociclib-induced neutropenia; T_lag: palbociclib absorption lag time; TR_X: transit compartments; V/F: palbociclib apparent volume of distribution.