Figure 3.

Simulation of the impact of different covariates’ values on ANC time course. (A) Simulations of palbociclib treatment with median covariates except Cl_cr. (B) Simulations of palbociclib treatment with median covariates except ALP. (C) Simulations of palbociclib treatment with median covariates except age. Cycle of 21 days of treatment (125 mg of palbociclib per day), then 7 days of therapeutic pause. In each graph, only one covariate is changed, the others are fixed at the median value. The extreme values of the covariates in the population were selected for each simulation.