Figure 3.

A diagram of a simplified nephron that summarizes possible mechanisms of transport for nanoparticles (NPs) and albumin. (a) A possible way albumin may be transcytosed from glomerular capillaries into tubules is through the FcRn receptor, which is expressed by podocytes. (b) Similarly, NPs may perhaps take the same route. (c) Reabsorption of albumin back into the bloodstream through interactions with the megalin/cubulin receptor complex, expressed by proximal convoluted tubule (PCT) cells. (d) A possible pathway for NPs being transcytosed via PCT cells is possibly also due to large absorptive pressure.