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. 2021 Oct 14;22(20):11093. doi: 10.3390/ijms222011093
AKI acute kidney injury
CKD chronic kidney disease
PTC proximal tubular cells
ESKD end-stage kidney disease
G0, G1, G2 phases gap 0, gap 1, gap 2 phases
S phase synthesis Phase
M phase mitosis phase
DNA deoxyribonucleic acid
PCNA proliferating cell nuclear antigen
BrdU bromodeoxyuridine
RPC renal progenitor cells
HDAC histone deacetylase
m4PTB methyl-4-(phenylthio) butanoate
TSA trichostatin
4-PBA 4-phenylbutyrate
ATM ataxia telangiectasia mutated
ATR ataxia telangiectasia and Rad3-related protein
CHK2 checkpoint kinase 2
TIMP2 tissue inhibitor of metalloproteinase 2
IGFBP7 insulin-like growth factor-binding protein 7
TGFβ transforming growth factor beta
CTGF connective tissue growth factor
JNK c-jun NH2- terminal kinase
MAPK mitogen-activated protein kinase
SASP senescence-associated secretory phenotype
snRNA-seq single nucleus cell RNA-seq
p-H3+ phospho-histone H3+
CDK cyclin dependent kinase
Smad small mother against decapentaplegic
UUO unilateral ureteral obstruction
PTBA phenylthiobutanoic acids
RPTEC Renal proximal tubular epithelial cells
YAP1 yes-associated protein 1
CDH1/FZR1 fizzy and cell division cycle 20 related 1
APC/C anaphase-promoting complex/cyclosome
LATS large tumor suppressor
E2F E2F Transcription Factor
NICD notch intracellular domain
EdU 3H-thymidine, 5-ethynyl-20-deoxyuridine
FUCCI2aR fluorescent ubiquitination-based cell cycle indicator
Cdt1 chromatin licensing and DNA replication factor1
GFP green fluorescent protein
YFP yellow fluorescent protein
RFP red fluorescent protein
CFP cyan fluorescent protein
KO knock-out
IRI ischemia reperfusion injury